Article
[Role of the liver-enriched transcription factor binding site mutation in the C promoter region of hepatitis B virus genome for HBx-enhanced hepatitis B virus replication].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 20 Apr 2021
Han N, Yan L L, Du L Y, Huang F J, Tang H
Abstract excerpt
Objective: To construct a recombinant HBV replication-type plasmid with liver-enriched transcription factor binding site mutation at proximal of HBV C promoter in order to elucidate the role of HBx-enhanced HBV replication. Methods: Site-directed mutagenesis technology was used to construct a recombinant plasmid with liver-enriched transcription factor binding site mutation at proximal of HBV C promoter on the...
Topics
- Animals
- Binding Sites
- Hepatitis B
- Hepatitis B virus
- Mice
- Mutation
- Promoter Regions, Genetic
- Trans-Activators
- Viral Regulatory and Accessory Proteins
- Virus Replication