Article
A mutant of hepatitis B virus X protein (HBxDelta127) promotes cell growth through a positive feedback loop involving 5-lipoxygenase and fatty acid synthase.
Neoplasia (New York, N.Y.) - 1 Feb 2010
Wang Qi, Zhang Weiying, Liu Qiang, Zhang Xuan, Lv Na, Ye Lihong, Zhang Xiaodong
Abstract excerpt
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Hepatitis B virus X protein (HBx) contributes to the development of HCC, whereas HBx with COOH-terminal deletion is a frequent event in the HCC tissues. Previously, we identified a natural mutant of HBx-truncated 27 amino acids at the COOH-terminal (termed HBxDelta127), which strongly enhanced cell growth. In the present study,...
Topics
Join the communities discussing this publication.