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Article

Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy.

The Journal of laryngology and otology - 1 May 2005

Capaccio Pasquale, Ottaviani Francesco, Cuccarini Valeria, Cenzuales Salvatore, Cesana Bruno Mario, Pignataro Lorenzo

Abstract excerpt

Folate metabolism dysregulation may lead to abnormal cell proliferation and predispose to carcinogenesis by inducing DNA hypomethylation. Folate pathways may be modified by polymorphisms in relevant genes, such as that for methylenetetrahydrofolate reductase (MTHFR), or by alcohol consumption. We...

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Source

Identifiers

PMID: 15949101
DOI: 10.1258/0022215053945831

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15949101-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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