Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy.

The Journal of laryngology and otology - 1 May 2005

Capaccio Pasquale, Ottaviani Francesco, Cuccarini Valeria, Cenzuales Salvatore, Cesana Bruno Mario, Pignataro Lorenzo

Abstract excerpt

Folate metabolism dysregulation may lead to abnormal cell proliferation and predispose to carcinogenesis by inducing DNA hypomethylation. Folate pathways may be modified by polymorphisms in relevant genes, such as that for methylenetetrahydrofolate reductase (MTHFR), or by alcohol consumption. We investigated the relationship between MTHFR mutations at nucleotides C677T and A1298C, which cause reduced MTHFR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Drinking
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Laryngeal Neoplasms

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Mouth Neoplasms

Share to Polymorphism, Genetic

Share to Risk Factors

Source

Identifiers

PMID: 15949101
DOI: 10.1258/0022215053945831

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between methylenetetrahydrofolate reductase polymorphisms, alcohol intake and oropharyngolaryngeal carcinoma in northern Italy.PMID 15949101Read ↗

Polymorphisms and haplotypes in methylenetetrahydrofolate reductase gene and head and neck squamous cell carcinoma risk.Semantic proximity Read ↗

Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer.Semantic proximity Read ↗

Polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and risk of head and neck squamous cell carcinoma.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control studies.Semantic proximity Read ↗

5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer.Semantic proximity Read ↗

Association between 11 genetic polymorphisms in folate-metabolising genes and head and neck cancer risk.Semantic proximity Read ↗

Folate-related genes and the risk of tobacco-related cancers in Central Europe.Semantic proximity Read ↗

Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer.Semantic proximity Read ↗

MTHFR C677T polymorphism interaction with heavy alcohol consumption increases head and neck carcinoma risk.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms and interaction with smoking and alcohol consumption in lung cancer risk: a case-control study in a Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.