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Article

Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan.

Carcinogenesis - 1 Jul 2005

Yang Chun-Xia, Matsuo Keitaro, Ito Hidemi, Shinoda Masayuki, Hatooka Shunzo, Hirose Kaoru, Wakai Kenji, Saito Toshiko, Suzuki Takeshi, Maeda Takako, Tajima Kazuo

Abstract excerpt

Folate takes part in two biological pathways involved in DNA methylation and synthesis, and a potential protective influence of this nutrient chemical against carcinogenicity has been recognized in several sites, including the esophagus. Therefore, the functional polymorphisms in genes encoding folate metabolizing enzymes, MTHFR C677T and MTR A2756G, might be suspected of impacting on esophageal cancer risk. We...

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Source

Identifiers

PMID: 15790587
DOI: 10.1093/carcin/bgi076

Genes

MTHFR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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