Article
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and susceptibility to gastric adenocarcinoma in an Italian population.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals - 1 Jan 2000
Boccia Stefania, Gianfagna Francesco, Persiani Roberto, La Greca Antonio, Arzani Dario, Rausei Stefano, D'ugo Domenico, Magistrelli Paolo, Villari Paolo, Van Duijn Cornelia M, Ricciardi Gualtiero
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the metabolism of folate, which provides a methyl donor for DNA methylation and deoxynucleoside synthesis. We performed a case-control study to explore the relationship between two common MTHFR polymorphisms (C677T and A1298C), their combination and interaction with environmental exposures, on gastric adenocarcinoma susceptibility and progression...
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