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Article

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.

The Journal of biological chemistry - 5 Aug 2005

Sansom Owen J, Reed Karen R, van de Wetering Marc, Muncan Vanesa, Winton Douglas J, Clevers Hans, Clarke Alan R

Abstract excerpt

Cyclin D1 is postulated to be a target of the canonical Wnt pathway and critical for intestinal adenoma development. We show here that, unlike cyclin D1 reporter assays, endogenous cyclin D1 levels are not affected following antagonism of the Wnt pathway in vitro, nor is cyclin D1 immediately up-regulated following conditional loss of Apc in vivo. Cyclin D1 levels do, however, increase in a delayed manner in a...

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Source

Identifiers

PMID: 15946945
DOI: 10.1074/jbc.M500191200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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