Vitamin D lowers the number of intestinal tumours in adult intestine-specific Apc-mutant mice only during early tumour initiation in gestation and juvenility.

Abstract excerpt

We reported earlier that adult FabplCre;Apc15lox/+ mice with either daily UV exposure or vitamin D supplementation developed not significantly fewer intestinal tumours but less tumour bulk (reduced outgrowth) than control mice that remained vitamin D deficient. Here, we report on a prior exploratory study in which parents (FabplCre and Apc15lox/15lox) and pups were fed either the vitamin D deficient (< 5 IU/kg)...

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