Article
Interaction between estrogen receptor 1 and the epsilon4 allele of apolipoprotein E increases the risk of familial Alzheimer's disease in women.
Neuroscience letters - 17 Mar 2000
Mattila K M, Axelman K, Rinne J O, Blomberg M, Lehtimäki T, Laippala P, Röyttä M, Viitanen M, Wahlund L, Winblad B, Lannfelt L
Abstract excerpt
Estrogens may be implicated in the development of Alzheimer's disease (AD). Most of their effects are mediated via receptors whose function and expression may be modified by DNA polymorphisms. Here the estrogen receptor 1 gene (ESR1) polymorphisms XbaI and PvuII were analyzed in 214 AD patients and 290 controls. In logistic regression analysis, a significantly increased risk of familial AD due to interaction...
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