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Article

A complementation method for functional analysis of mammalian genes.

Nucleic acids research - 8 Jun 2005

Gonzalez-Santos Juana Maria, Cao Huibi, Wang Anan, Koehler David R, Martin Bernard, Navab Roya, Hu Jim

Abstract excerpt

Our progress in understanding mammalian gene function has lagged behind that of gene identification. New methods for mammalian gene functional analysis are needed to accelerate the process. In yeast, the powerful genetic shuffle system allows deletion of any chromosomal gene by homologous recombination and episomal expression of a mutant allele in the same cell. Here, we report a method for mammalian cells, which...

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PMID: 15944448
DOI: 10.1093/nar/gni093
PMCID: PMC1145195

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PRPF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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