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A High-Efficiency Cre/loxP-Based System for Construction of Adenoviral Vectors

10 Nov 1999

Abstract excerpt

Adenovirus (Ad) vectors provide a highly efficient means of mammalian gene transfer and are widely used for high-level protein expression in mammalian cells, as recombinant vaccines and for gene therapy. A commonly used method for constructing Ad vectors relies on in vivo homologous recombination between two Ad DNA-containing bacterial plasmids cotransfected into 293 cells. While the utility of this two-plasmid...

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PMID: 10566894
DOI: 10.1089/10430349950016708

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