Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models.

Proceedings of the National Academy of Sciences of the United States of America - 30 Dec 2014

Jiang Ke, Wright Katherine L, Zhu Ping, Szego Michael J, Bramall Alexa N, Hauswirth William W, Li Qiuhong, Egan Sean E, McInnes Roderick R

Abstract excerpt

Inherited photoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by mutations in more than 200 genes, but little is known about the molecular pathogenesis of photoreceptor (PR) death. Increased retinal expression of STAT3 has been observed in response to many retinal insults, including IPDs, but the role of this increase in PR death is unknown. Here, we show that the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Diseases, Inborn

Share to Mice, Transgenic

Share to Photoreceptor Cells, Vertebrate

Share to Retinal Degeneration

Share to RNA, Untranslated

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 25512545
DOI: 10.1073/pnas.1411248112
PMCID: PMC4284576

Genes

STAT3
RHO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models.PMID 25512545Read ↗

Elevating Jak-STAT signaling via SOCS3 deletion sustains photoreceptor viability and visual function in mouse models of retinitis pigmentosaSemantic proximity Read ↗

Differential role of Jak‐STAT signaling in retinal degenerationsSemantic proximity Read ↗

RIPK3 suppresses photoreceptor degeneration in a Stargardt disease mouse modelSemantic proximity Read ↗

Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degenerationSemantic proximity Read ↗

Preventing light-induced toxicity in a new mouse model of rhodopsin sector retinitis pigmentosaSemantic proximity Read ↗

Augmentation of CD47-SIRPα signaling protects cones in genetic models of retinal degenerationSemantic proximity Read ↗

A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration.Semantic proximity Read ↗

HDAC inhibition ameliorates cone survival in retinitis pigmentosa miceSemantic proximity Read ↗

Progressive retinal degeneration and dysfunction in R6 Huntington's disease miceSemantic proximity Read ↗

Subcellular localization of mutant P23H rhodopsin in an RFP fusion knockin mouse model of retinitis pigmentosaSemantic proximity Read ↗

Ablation of the proapoptotic genes CHOP or Ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa.Semantic proximity Read ↗

Endothelin-2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.