[Mechanisms for the development of quinolone resistance].

Article

[Mechanisms for the development of quinolone resistance].

Nihon rinsho. Japanese journal of clinical medicine - 1 May 1997

Kojima M

Abstract excerpt

New fluoroquinolones have potent and broad antimicrobial activity and spectra, respectively, against gram-positive and -negative bacteria including P. aeruginosa. As a result of their frequent use, bacterial resistance to the quinolones has gradually developed and limited their therapeutic effica...

Topics

Anti-Infective Agents
Antiporters
Bacteria
Bacterial Outer Membrane Proteins
Cell Membrane Permeability
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II
Drug Resistance, Microbial
Fluoroquinolones
Mutation

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