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Article

Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection

14 Apr 2003

Abstract excerpt

Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump...

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PMID: 12697644
DOI: 10.1093/jac/dkg222

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Source receipt: pubmed, retrieved 7 Sept 2026.

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