Article
Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2005
Robinson James P, Johnson Victoria L, Rogers Pauline A, Houlston Richard S, Maher Earmonn R, Bishop D Timothy, Evans D Gareth R, Thomas Huw J W, Tomlinson Ian P M, Silver Andrew R J
Abstract excerpt
Whereas a recent study reported an increased risk of colorectal cancer associated with any HFE germ line mutation (C282Y or H63D), other investigators have concluded there is no increased risk, or that any increase is dependent on polymorphisms in HFE-interacting genes such as the transferrin receptor (TFR). We have established the frequency of HFE mutations in colorectal cancer patients (n = 327) with a family...
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