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Article

No evidence of increased risk of colorectal cancer in individuals heterozygous for the Cys282Tyr haemochromatosis mutation.

Journal of gastroenterology and hepatology - 1 Dec 1999

Macdonald G A, Tarish J, Whitehall V J, McCann S J, Mellick G D, Buttenshaw R L, Johnson A G, Young J, Leggett B A

Abstract excerpt

BACKGROUND AND AIMS: Previous studies have suggested that increased body iron stores and heterozygosity for haemochromatosis are associated with an increased risk of colorectal carcinoma. The aim of this study is to determine if there is an association between (i) colorectal carcinoma and heterozygosity for the Cys282Tyr mutation of the haemochromatosis gene (HFE) and (ii) this mutation and tumour site or stage....

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Source

Identifiers

PMID: 10634155
DOI: 10.1046/j.1440-1746.1999.02027.x

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

No evidence of increased risk of colorectal cancer in individuals heterozygous for the Cys282Tyr haemochromatosis mutation.PMID 10634155Read ↗

Heterozygosity for the Cys282Tyr mutation in the HFE gene and the risk of colorectal cancer (Netherlands).Semantic proximity Read ↗

HFE C282Y homozygotes are at increased risk of breast and colorectal cancer.Semantic proximity Read ↗

Hemochromatosis gene mutations and distal adenomatous colorectal polyps.Semantic proximity Read ↗

Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis (HFE) gene and increased risk of colorectal cancer.Semantic proximity Read ↗

Colorectal cancer risk is not associated with increased levels of homozygosity in a population from the United Kingdom.Semantic proximity Read ↗

Cancer risk in HFE C282Y homozygotes: results from the HUNT 2 study.Semantic proximity Read ↗

Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women.Semantic proximity Read ↗

Haemochromatosis HFE gene polymorphisms as potential modifiers of hereditary nonpolyposis colorectal cancer risk and onset age.Semantic proximity Read ↗

Linkage disequilibrium between the 677C>T and 1298A>C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer.Semantic proximity Read ↗

Increased frequency of the haemochromatosis Cys282Tyr mutation in sporadic porphyria cutanea tarda.Semantic proximity Read ↗

Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer.Semantic proximity Read ↗

XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma.Semantic proximity Read ↗

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