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Article

Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer.

Journal of the National Cancer Institute - 15 Jan 2003

Shaheen Nicholas J, Silverman Lawrence M, Keku Temitope, Lawrence Laura B, Rohlfs Elizabeth M, Martin Christopher F, Galanko Joseph, Sandler Robert S

Abstract excerpt

BACKGROUND: Iron is a pro-oxidant that may promote carcinogenesis. Mutations in the hemochromatosis (HFE) gene are associated with increased total body iron stores in some individuals. We assessed the risk of colon cancer among individuals with and without HFE gene mutations. METHODS: We performe...

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Identifiers

PMID: 12529348
DOI: 10.1093/jnci/95.2.154

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12529348-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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