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Article

Germ cell specification in mice.

Science (New York, N.Y.) - 20 Apr 2007

Hayashi Katsuhiko, de Sousa Lopes Susana M Chuva, Surani M Azim

Abstract excerpt

Specification of germ cells in mice occurs relatively late in embryonic development. It is initiated by signals that induce expression of Blimp1, a key regulator of the germ cell, in a few epiblast cells of early postimplantation embryos. Blimp1 represses the incipient somatic program in these cells and promotes progression toward the germ cell fate. Blimp1 may also have a role in the maintenance of early germ...

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Identifiers

PMID: 17446386
DOI: 10.1126/science.1137545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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