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Article

The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice.

Nature communications - 3 Jun 2020

Goolam Mubeen, Xypolita Maria-Eleni, Costello Ita, Lydon John P, DeMayo Francesco J, Bikoff Elizabeth K, Robertson Elizabeth J, Mould Arne W

Abstract excerpt

The transcriptional repressor Blimp1 controls cell fate decisions in the developing embryo and adult tissues. Here we describe Blimp1 expression and functional requirements within maternal uterine tissues during pregnancy. Expression is robustly up-regulated at early post-implantation stages in the primary decidual zone (PDZ) surrounding the embryo. Conditional inactivation results in defective formation of the...

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Identifiers

PMID: 32493987
DOI: 10.1038/s41467-020-16603-z
PMCID: PMC7270082

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