Article
Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression.
Neuroscience - 18 Feb 2009
Giralt A, Rodrigo T, Martín E D, Gonzalez J R, Milà M, Ceña V, Dierssen M, Canals J M, Alberch J
Abstract excerpt
The involvement of brain-derived neurotrophic factor (BDNF) in cognitive processes and the decrease in its expression in Huntington's disease suggest that this neurotrophin may play a role in learning impairment during the disease progression. We therefore analyzed the onset and severity of cognitive deficits in two different mouse models with the same mutant huntingtin but with different levels of BDNF (R6/1 and...
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