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Article

Crystal structure of a SeqA-N filament: implications for DNA replication and chromosome organization.

The EMBO journal - 20 Apr 2005

Guarné Alba, Brendler Therese, Zhao Qinghai, Ghirlando Rodolfo, Austin Stuart, Yang Wei

Abstract excerpt

Escherichia coli SeqA binds clusters of transiently hemimethylated GATC sequences and sequesters the origin of replication, oriC, from methylation and premature reinitiation. Besides oriC, SeqA binds and organizes newly synthesized DNA at replication forks. Binding to multiple GATC sites is crucial for the formation of stable SeqA-DNA complexes. Here we report the crystal structure of the oligomerization domain...

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Share to Bacterial Outer Membrane Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15933720
DOI: 10.1038/sj.emboj.7600634
PMCID: PMC1142570

Genes

GATC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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