Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Binding of SeqA protein to hemi-methylated GATC sequences enhances their interaction and aggregation properties.

The Journal of biological chemistry - 16 Jul 2004

Han Joo Seok, Kang Sukhyun, Kim Sung Ho, Ko Min Ji, Hwang Deog Su

Abstract excerpt

The SeqA protein regulates chromosome initiation and is involved in segregation in Escherichia coli. One SeqA protein binds to two hemi-methylated GATC sequences to form a stable SeqA-DNA complex. We found that binding induced DNA bending, which was pronounced when the two sequences were on the same face of the DNA. Two SeqA molecules bound cooperatively to each pair of hemi-methylated sites when the spacing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Outer Membrane Proteins
Share to Chelating Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Copper

Share to DNA Methylation

Share to Dose-Response Relationship, Drug

Share to Escherichia coli Proteins

Share to Plasmids

Source

Identifiers

PMID: 15151991
DOI: 10.1074/jbc.M402612200

Genes

GATC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding of SeqA protein to hemi-methylated GATC sequences enhances their interaction and aggregation properties.PMID 15151991Read ↗

Crystal structure of a SeqA-N filament: implications for DNA replication and chromosome organization.Semantic proximity Read ↗

The Escherichia coli SeqA protein.Semantic proximity Read ↗

Crystallization and preliminary X-ray diffraction analysis of SeqA bound to a pair of hemimethylated GATC sites.Semantic proximity Read ↗

SeqA, the Escherichia coli origin sequestration protein, is also a specific transcription factor.Semantic proximity Read ↗

Lack of SeqA focus formation, specific DNA binding and proper protein multimerization in the Escherichia coli sequestration mutant seqA2.Semantic proximity Read ↗

Replication fork inhibition in seqA mutants of Escherichia coli triggers replication fork breakage.Semantic proximity Read ↗

GATC flanking sequences regulate Dam activity: evidence for how Dam specificity may influence pap expression.Semantic proximity Read ↗

SeqA limits DnaA activity in replication from oriC in Escherichia coli.Semantic proximity Read ↗

The synchrony phenotype persists after elimination of multiple GATC sites from the dnaA promoter of Escherichia coli.Semantic proximity Read ↗

Bacillus subtilis ParB C-terminal lysine residues are essential for dimerization and in vivo function, indicating their roles in DNA sliding.Semantic proximity Read ↗

Asymmetric DNA methylation by dimeric EcoP15I DNA methyltransferase.Semantic proximity Read ↗

Insights into the Structure of Sulfolobus Nucleoid Using Engineered Sac7d Dimers with a Defined Orientation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.