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Article

Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease.

Journal of neurology, neurosurgery, and psychiatry - 1 Mar 2004

Mosconi L, Nacmias B, Sorbi S, De Cristofaro M T R, Fayazz M, Tedde A, Bracco L, Herholz K, Pupi A

Abstract excerpt

OBJECTIVES: Declines in brain glucose metabolism have been described early in Alzheimer's disease (AD), and there is evidence that a genetic predisposition to AD contributes to accelerate this process. The epsilon 4 (e4) allele of the apolipoprotein E (ApoE) gene has been implicated as a major ri...

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Identifiers

PMID: 14966149
DOI: 10.1136/jnnp.2003.014993
PMCID: PMC1738980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14966149-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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