Article
Comparative analysis of mutation frequency of coding and non coding short mononucleotide repeats in mismatch repair deficient colorectal cancers.
Oncogene - 14 Nov 2002
Duval Alex, Reperant Maryline, Hamelin Richard
Abstract excerpt
Coding repeats are usually short mononucleotide tracts (SMT) of 10 or less base pairs in size. A number of such sequences contained in genes suspected to play a role in human carcinogenesis have been found to be mutated in mismatch repair deficient tumors (MSI-H cancers). Because of the high background of instability characterizing these cancers and in the absence of functional criteria, the significance of most...
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