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Article

Alx4 and Msx2 play phenotypically similar and additive roles in skull vault differentiation.

Journal of anatomy - 1 Jun 2004

Antonopoulou Ileana, Mavrogiannis Lampros A, Wilkie Andrew O M, Morriss-Kay Gillian M

Abstract excerpt

Alx4 and Msx2 encode homeodomain-containing transcription factors that show a clear functional overlap. In both mice and humans, loss of function of either gene is associated with ossification defects of the skull vault, although the major effect is on the frontal bones in mice and the parietal bones in humans. This study was undertaken to discover whether Alx4 and Msx2 show a genetic interaction in skull vault...

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Identifiers

PMID: 15198690
DOI: 10.1111/j.0021-8782.2004.00304.x
PMCID: PMC1571319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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