Article
Systematic analysis of human kinase genes: a large number of genes and alternative splicing events result in functional and structural diversity.
BMC bioinformatics - 1 Dec 2005
Milanesi Luciano, Petrillo Mauro, Sepe Leandra, Boccia Angelo, D'Agostino Nunzio, Passamano Myriam, Di Nardo Salvatore, Tasco Gianluca, Casadio Rita, Paolella Giovanni
Abstract excerpt
BACKGROUND: Protein kinases are a well defined family of proteins, characterized by the presence of a common kinase catalytic domain and playing a significant role in many important cellular processes, such as proliferation, maintenance of cell shape, apoptosis. In many members of the family, additional non-kinase domains contribute further specialization, resulting in subcellular localization, protein binding...
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