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Article

A dominant interfering Myb mutant causes apoptosis in T cells.

Genes & development - 1 Nov 1996

Taylor D, Badiani P, Weston K

Abstract excerpt

The c-Myb transcription factor is required for the production of most hemopoietic lineages, but information is sparse about its mode of action and the key genes it regulates. We have made an inducible dominant interfering Myb protein, by creating a chimera comprising the DNA binding domain of c-Myb, the Drosophila Engrailed repressor domain, and a modified estrogen receptor hormone binding domain. When expressed...

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Identifiers

PMID: 8946914
DOI: 10.1101/gad.10.21.2732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A dominant interfering Myb mutant causes apoptosis in T cells.PMID 8946914Read ↗

Dominant interfering alleles define a role for c-Myb in T-cell development.Semantic proximity Read ↗

Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved.Semantic proximity Read ↗

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.Semantic proximity Read ↗

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Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development.Semantic proximity Read ↗

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MYB Is Essential for Mammary TumorigenesisSemantic proximity Read ↗

Generation of a conditional allele of the B-myb gene.Semantic proximity Read ↗

Exon Skipping in Mcl-1 Results in a Bcl-2 Homology Domain 3 Only Gene Product That Promotes Cell DeathSemantic proximity Read ↗

MYBsuppresses differentiation and apoptosis of human breast cancer cellsSemantic proximity Read ↗

Use of gene knockouts in cultured cells to study apoptosis.Semantic proximity Read ↗

Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic PathwaySemantic proximity Read ↗

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