A dominant interfering Myb mutant causes apoptosis in T cells.

doi:10.1101/gad.10.21.2732

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Article

A dominant interfering Myb mutant causes apoptosis in T cells.

Genes & development - 1 Nov 1996

Taylor D, Badiani P, Weston K

Abstract excerpt

The c-Myb transcription factor is required for the production of most hemopoietic lineages, but information is sparse about its mode of action and the key genes it regulates. We have made an inducible dominant interfering Myb protein, by creating a chimera comprising the DNA binding domain of c-M...

Topics

3T3 Cells
Alleles
Animals
Apoptosis
Genes, Dominant
Mice
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Proto-Oncogene Proteins c-myb
T-Lymphocytes
Thymus Gland
Trans-Activators

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