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Article

Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb.

The EMBO journal - 1 Sept 2003

Emambokus Nikla, Vegiopoulos Alexandros, Harman Ben, Jenkinson Eric, Anderson Graham, Frampton Jon

Abstract excerpt

The c-Myb transcription factor is expressed in immature haemopoietic cells and at key stages during differentiation. Loss of the c-myb gene results in embryonic lethality because mature blood cells fail to develop, although commitment to definitive haemopoiesis occurs. We have generated a knockdown allele of c-myb, expressing low levels of the protein, which has enabled us to investigate further the involvement...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12941699
DOI: 10.1093/emboj/cdg434
PMCID: PMC202376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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