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Article

Modifications to the hemagglutinin cleavage site control the virulence of a neurotropic H1N1 influenza virus.

Journal of virology - 1 Sept 2010

Sun Xiangjie, Tse Longping V, Ferguson A Damon, Whittaker Gary R

Abstract excerpt

A key determinant of influenza virus pathogenesis is mutation in the proteolytic cleavage site of the hemagglutinin (HA). Typically, low-pathogenicity forms of influenza virus are cleaved by trypsin-like proteases, whereas highly pathogenic forms are cleaved by different proteases (e.g., furin). Influenza virus A/WSN/33 (WSN) is a well-studied H1N1 strain that is trypsin independent in vitro and has the ability...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H1N1 Subtype

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Source

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Identifiers

PMID: 20554779
DOI: 10.1128/JVI.00797-10
PMCID: PMC2919019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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