Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies.

doi:10.1093/annonc/mdi907

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Article

Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2005

Russo A, Bazan V, Agnese V, Rodolico V, Gebbia N

Abstract excerpt

Mutations in the Ki-ras and TP53 genes are the most frequently observed genetic alterations in colorectal cancer (CRC). Ki-ras mutations are mostly found in codons 12 and 13, and less in codon 61. The majority of the TP53 mutations occur in the core domain which contains the sequence-specific DNA binding activity of the protein, and they results in loss of DNA binding. Few centres have sufficient patients to...

Topics

Colorectal Neoplasms
Fluorouracil
Mutation
Predictive Value of Tests
Prognosis
Proto-Oncogene Proteins
Proto-Oncogene Proteins p21(ras)
Survival Rate
Tumor Suppressor Protein p53
ras Proteins

Source

Open in PubMed

Identifiers

PMID: 15923428
DOI: 10.1093/annonc/mdi907

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