Article
Mutation and methylation analysis of TP53 in adrenal carcinogenesis.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Jun 2005
Sidhu S, Martin E, Gicquel C, Melki J, Clark S J, Campbell P, Magarey C J, Schulte K M, Röher H D, Delbridge L, Robinson B G
Abstract excerpt
AIM: To investigate the role of coding region mutation and promoter hypermethylation of TP53 in adrenocortical cancer formation. METHODS: Twenty sporadic adrenocortical cancers (ACCs) and five normal adrenal tissue samples were available for analysis. Coding region mutation of TP53 in 20 ACCs was examined by polymerase chain amplification using intronic primers for exons 2-11 and direct sequencing of the product....
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