Tumors associated with p53 germline mutations: a synopsis of 91 families.

Article

Tumors associated with p53 germline mutations: a synopsis of 91 families.

The American journal of pathology - 1 Jan 1997

Kleihues P, Schäuble B, zur Hausen A, Estève J, Ohgaki H

Abstract excerpt

Although inherited p53 mutations are present in all somatic cells, malignant transformation is limited to certain organs and target cells. The analysis of 475 tumors in 91 families with p53 germline mutations reported since 1990 shows that breast carcinomas are most frequent (24.0%), followed by...

Topics

Disease Susceptibility
Genes, p53
Humans
Mutation
Neoplasms

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