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Article

Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a children's oncology group study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Feb 2015

Wasserman Jonathan D, Novokmet Ana, Eichler-Jonsson Claudia, Ribeiro Raul C, Rodriguez-Galindo Carlos, Zambetti Gerard P, Malkin David

Abstract excerpt

PURPOSE: Adrenocortical carcinoma (ACC) is a rare pediatric malignancy. It occurs in excess among individuals with the Li-Fraumeni syndrome, which results primarily from germline mutations in the TP53 gene. Prior series exploring frequencies of germline TP53 mutation among children with ACC have been small, geographically limited, or subject to referral bias. The functional consequence of mutations has not been...

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Identifiers

PMID: 25584008
DOI: 10.1200/JCO.2013.52.6863
PMCID: PMC4517369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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