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Article

TP53 germline mutations in adult patients with adrenocortical carcinoma.

The Journal of clinical endocrinology and metabolism - 1 Mar 2012

Herrmann Leonie J M, Heinze Britta, Fassnacht Martin, Willenberg Holger S, Quinkler Marcus, Reisch Nicole, Zink Martina, Allolio Bruno, Hahner Stefanie

Abstract excerpt

CONTEXT: Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome associated with germline mutations in TP53. According to the Chompret criteria for LFS, any patient with adrenocortical cancer (ACC), irrespective of age and family history, is at high risk for a TP53 germline mutation. However, whereas such mutations have been detected with high frequency in childhood ACC, a large cohort of adult patients...

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Identifiers

PMID: 22170717
DOI: 10.1210/jc.2011-1982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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