Article
Prevalence of germline TP53 mutations in a prospective series of unselected patients with adrenocortical carcinoma.
The Journal of clinical endocrinology and metabolism - 1 Jan 2013
Raymond Victoria M, Else Tobias, Everett Jessica N, Long Jessica M, Gruber Stephen B, Hammer Gary D
Abstract excerpt
PURPOSE: Adrenocortical carcinoma (ACC) is a hallmark cancer in families with Li Fraumeni syndrome (LFS) caused by mutations in the TP53 gene. The prevalence of germline TP53 mutations in children diagnosed with ACC ranges from 50-97%. Although existing criteria advocate for TP53 testing in all patients with ACC regardless of age at diagnosis, the overall prevalence of germline mutations in patients diagnosed...
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