Article
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and susceptibility to pediatric acute lymphoblastic leukemia in a German study population.
BMC medical genetics - 27 May 2005
Schnakenberg Eckart, Mehles Andrea, Cario Gunnar, Rehe Klaus, Seidemann Kathrin, Schlegelberger Brigitte, Elsner Holger A, Welte Karl H, Schrappe Martin, Stanulla Martin
Abstract excerpt
BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) has a major impact on the regulation of the folic acid pathway due to conversion of 5,10-methylenetetrahydrofolate (methylene-THF) to 5-methyl-THF. Two common polymorphisms (677C>T and 1298A>C) in the gene coding for MTHFR have been shown to reduce MTHFR enzyme activity and were associated with the susceptibility to different disorders, including vascular...
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