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Article

Methylenetetrahydrofolate reductase genotypes do not play a role in acute lymphoblastic leukemia pathogenesis in the Italian population.

Haematologica - 1 Feb 2004

Chiusolo Patrizia, Reddiconto Giovanni, Cimino Giuseppe, Sica Simona, Fiorini Alessia, Farina Giuliana, Vitale Antonella, Sorà Federica, Laurenti Luca, Bartolozzi Francesco, Fazi Paola, Mandelli Franco, Leone Giuseppe

Abstract excerpt

BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and DNA methylation and synthesis. Some genotypes of this highly polymorphic enzyme are associated with decreased activity. Previous studies have suggested that individuals with the MTHFR 677TT, 1298AC and 1298CC have a lower risk of adult acute lymphoblastic leukemia (ALL). DESIGN AND...

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Identifiers

PMID: 15003888

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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