Article
Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations.
Biochemical and biophysical research communications - 8 Jul 2005
Becker T M, Rizos H, de la Pena A, Leclercq I A, Woodruff S, Kefford R F, Mann G J
Abstract excerpt
The cyclin-dependent kinase inhibitor p16INK4a has been identified as tumor suppressor and melanoma predisposition gene. While its cell cycle inhibitory ability is important in protecting cells from uncontrolled growth and possible tumor formation, other functions of p16INK4a are likely to contribute to its nature as a tumor suppressor. p16INK4a binding and inhibition of the transcription factor NF-kappaB has...
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