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Article

The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a

1 Jan 2009

Abstract excerpt

BACKGROUND: CDKN2A/p16INK4a is frequently altered in human cancers and it is the most important melanoma susceptibility gene identified to date. p16INK4a inhibits pRb phosphorylation and induces cell cycle arrest, which is considered its main tumour suppressor function. Nevertheless, additional activities may contribute to the tumour suppressor role of p16INK4a and could help explain its specific association with...

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PMID: 19149898
DOI: 10.1186/1476-4598-8-4

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