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Article

The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA.

Molecular immunology - 1 Mar 1990

Eilat D

Abstract excerpt

Several distinctive features of anti-DNA autoantibodies have been identified by a detailed analysis of the available heavy and light chain sequences. They include unique VH gene segments that are not normally expressed in antibodies to external antigens, somatic mutations which may serve to change the antigenic specificity as well as to increase affinity, a less stringent choice of light chains, and a unique...

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PMID: 2188119
DOI: 10.1016/0161-5890(90)90131-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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