The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA.

doi:10.1016/0161-5890(90)90131-i

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Article

The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA.

Molecular immunology - 1 Mar 1990

Eilat D

Abstract excerpt

Several distinctive features of anti-DNA autoantibodies have been identified by a detailed analysis of the available heavy and light chain sequences. They include unique VH gene segments that are not normally expressed in antibodies to external antigens, somatic mutations which may serve to chang...

Topics

Amino Acid Sequence
Animals
Antibodies, Antinuclear
Base Sequence
DNA
Gene Expression
Genes, Immunoglobulin
Humans
Lupus Erythematosus, Systemic
Mice
Molecular Sequence Data
Mutation

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