Article
Studies on the structure, regulation, and pathogenic potential of anti-dsDNA antibodies.
Methods (San Diego, Calif.) - 1 Jan 1997
Spatz L, Iliev A, Saenko V, Jones L, Irigoyen M, Manheimer-Lory A, Gaynor B, Putterman C, Bynoe M, Kowal C, Kuo P, Newman J, Diamond B
Abstract excerpt
Studies of anti-double-stranded (anti-ds)DNA antibodies have provided insights into how and why these antibodies arise in systemic lupus erythematosus. In this review we discuss the experimental approaches that have been used by our laboratory to study these autoantibodies. Structure/function analyses including site-directed mutagenesis have helped characterize the molecular genetics of anti-dsDNA antibodies, and...
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