Article
The evolution of human anti-double-stranded DNA autoantibodies.
Proceedings of the National Academy of Sciences of the United States of America - 28 Jun 2005
Wellmann Ute, Letz Miriam, Herrmann Martin, Angermüller Sieglinde, Kalden Joachim R, Winkler Thomas H
Abstract excerpt
It has been proposed that the anti-double-stranded DNA (dsDNA) response in patients with systemic lupus erythematosus (SLE) is antigen driven and that DNA or nucleosomes select anti-DNA reactive, somatically mutated B cells. We have used site-directed mutagenesis to systematically revert the somatic mutations of two human anti-dsDNA antibodies from SLE patients to analyze the resulting changes in DNA binding as...
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