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Article

The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.

Cell cycle (Georgetown, Tex.) - 1 Jun 2005

Eyers Patrick A, Churchill Mair E A, Maller James L

Abstract excerpt

The Aurora A and B protein kinases are key players in mitotic control and the etiology of human cancer. Despite the near identity of amino acid sequence in the catalytic domain, monomeric Aurora B is 50 fold lower in activity than monomeric Aurora A, and previous studies have shown that TPX2 bind...

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Source

Identifiers

PMID: 15908779
DOI: 10.4161/cc.4.6.1693

Genes

TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15908779-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.PMID 15908779Read ↗

Regulation of Xenopus Aurora A activation by TPX2.Semantic proximity Read ↗

Determinants for Aurora-A activation and Aurora-B discrimination by TPX2.Semantic proximity Read ↗

A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2.Semantic proximity Read ↗

Computational investigation of cancer-associated molecular mechanism in Aurora A (S155R) mutation.Semantic proximity Read ↗

Aurora kinase A, a synthetic lethal target for precision cancer medicineSemantic proximity Read ↗

Aurora B Inhibitors as Cancer TherapeuticsSemantic proximity Read ↗

Identification of small molecule inhibitors of the Aurora-A/TPX2 complexSemantic proximity Read ↗

Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases.Semantic proximity Read ↗

Development of a Chemical Genetic Approach for Human Aurora B Kinase Identifies Novel Substrates of the Chromosomal Passenger ComplexSemantic proximity Read ↗

The Aurora kinases: role in cell transformation and tumorigenesis.Semantic proximity Read ↗

BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition.Semantic proximity Read ↗

Two TPX2-dependent switches control the activity of Aurora A.Semantic proximity Read ↗

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