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Article

Regulation of Xenopus Aurora A activation by TPX2.

The Journal of biological chemistry - 5 Mar 2004

Eyers Patrick A, Maller James L

Abstract excerpt

The oncogenic protein kinase Aurora A is a critical regulator of meiotic and mitotic cell cycles in eukaryotic cells. Aurora A autoactivation by autophosphorylation is promoted by specific non-catalytic binding proteins. One such protein is TPX2, a required spindle assembly factor in higher eukaryotes whose ability to activate Aurora A by direct binding to the kinase catalytic domain has been established by...

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Source

Identifiers

PMID: 14701852
DOI: 10.1074/jbc.M312424200

Genes

TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence.

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Regulation of Xenopus Aurora A activation by TPX2.PMID 14701852Read ↗

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Tpx2 Controls Spindle Integrity, Genome Stability, and Tumor DevelopmentSemantic proximity Read ↗

Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2Semantic proximity Read ↗

TPX2.Semantic proximity Read ↗

A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2.Semantic proximity Read ↗

Functional divergence of TPX2 family members in Arabidopsis thalianaSemantic proximity Read ↗

Identification of small molecule inhibitors of the Aurora-A/TPX2 complexSemantic proximity Read ↗

Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycleSemantic proximity Read ↗

Computational investigation of cancer-associated molecular mechanism in Aurora A (S155R) mutation.Semantic proximity Read ↗

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A ActivitySemantic proximity Read ↗

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