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Article

Functional Role of Histidine in the Conserved His-x-Asp Motif in the Catalytic Core of Protein Kinases.

Scientific reports - 11 May 2015

Zhang Lun, Wang Jian-Chuan, Hou Li, Cao Peng-Rong, Wu Li, Zhang Qian-Sen, Yang Huai-Yu, Zang Yi, Ding Jian-Ping, Li Jia

Abstract excerpt

The His-x-Asp (HxD) motif is one of the most conserved structural components of the catalytic core of protein kinases; however, the functional role of the conserved histidine is unclear. Here we report that replacement of the HxD-histidine with Arginine or Phenylalanine in Aurora A abolishes both the catalytic activity and auto-phosphorylation, whereas the Histidine-to-tyrosine impairs the catalytic activity...

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Identifiers

PMID: 25960268
DOI: 10.1038/srep10115
PMCID: PMC4650784

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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