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Article

Computational investigation of cancer-associated molecular mechanism in Aurora A (S155R) mutation.

Cell biochemistry and biophysics - 1 Jul 2013

Kumar Ambuj, Rajendran Vidya, Sethumadhavan Rao, Purohit Rituraj

Abstract excerpt

Centrosomes are the key-regulating element of cell cycle progression. Aberrations in their functional mechanism lead to several cancer-related disorders. Aurora A protein is a centrosome-associated protein that regulates the centriole duplication and its abberations are associated with multiple cases of aneuploidy and cancer-related disorders. S155R mutation in Aurora A is reported to induce cancer like phenotype...

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Source

Identifiers

PMID: 23412841
DOI: 10.1007/s12013-013-9524-9

Genes

TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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