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Article

A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2.

The Journal of biological chemistry - 27 Nov 2009

Bibby Rachel Ann, Tang Chan, Faisal Amir, Drosopoulos Konstantinos, Lubbe Steven, Houlston Richard, Bayliss Richard, Linardopoulos Spiros

Abstract excerpt

Mutations in protein kinases can drive cancer through alterations of the kinase activity or by uncoupling kinase activity from regulation. Changes to protein expression in Aurora A, a mitotic Ser/Thr kinase, are associated with the development of several human cancers, but the effects of somatic...

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Source

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Identifiers

PMID: 19801554
DOI: 10.1074/jbc.M109.032722
PMCID: PMC2785160

Genes

TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19801554-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2.PMID 19801554Read ↗

The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.Semantic proximity Read ↗

Computational investigation of cancer-associated molecular mechanism in Aurora A (S155R) mutation.Semantic proximity Read ↗

Regulation of Xenopus Aurora A activation by TPX2.Semantic proximity Read ↗

Phosphorylation of NuMA by Aurora-A kinase in PC-3 prostate cancer cells affects proliferation, survival, and interphase NuMA localization.Semantic proximity Read ↗

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cellsSemantic proximity Read ↗

Localization of Human TACC3 to Mitotic Spindles Is Mediated by Phosphorylation on Ser558 by Aurora A: A Novel Pharmacodynamic Method for Measuring Aurora A ActivitySemantic proximity Read ↗

Development of a Chemical Genetic Approach for Human Aurora B Kinase Identifies Novel Substrates of the Chromosomal Passenger ComplexSemantic proximity Read ↗

Cancer-associated DAXX mutations reveal a critical role for ATRX localization in ALT suppressionSemantic proximity Read ↗

Control of Aurora-A stability through interaction with TPX2Semantic proximity Read ↗

Aurora-A/STK15 T+91A is a general low penetrance cancer susceptibility gene: a meta-analysis of multiple cancer types.Semantic proximity Read ↗

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human.Semantic proximity Read ↗

The N-terminal domain of the Aurora-A Phe-31 variant encodes an E3 ubiquitin ligase and mediates ubiquitination of IkappaBalpha.Semantic proximity Read ↗

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