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Article

Two TPX2-dependent switches control the activity of Aurora A.

PloS one - 9 Feb 2011

Xu Xue, Wang Xia, Xiao Zhengtao, Li Yan, Wang Yonghua

Abstract excerpt

Aurora A is an important oncogenic kinase for mitotic spindle assembly and a potentially attractive target for human cancers. Its activation could be regulated by ATP cycle and its activator TPX2. To understand the activation mechanism of Aurora A, a series of 20 ns molecular dynamics (MD) simulations were performed on both the wild-type kinase and its mutants. Analyzing the three dynamic trajectories (Aurora...

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Share to Adenosine Diphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21347367
DOI: 10.1371/journal.pone.0016757
PMCID: PMC3036663

Genes

TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Two TPX2-dependent switches control the activity of Aurora A.PMID 21347367Read ↗

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The Aurora A and Aurora B protein kinases: a single amino acid difference controls intrinsic activity and activation by TPX2.Semantic proximity Read ↗

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