Article
TNFalpha contributes to the death of NGF-dependent neurons during development.
Nature neuroscience - 1 Dec 2001
Barker V, Middleton G, Davey F, Davies A M
Abstract excerpt
Many sympathetic and sensory neurons depend on a supply of nerve growth factor (NGF) from their targets during development, and neurons that fail to obtain sufficient NGF die by apoptosis. Here we show that tumor necrosis factor alpha (TNFalpha) is involved in bringing about the death of NGF-deprived neurons. Function-blocking antibodies against either TNFalpha or TNF receptor 1 (TNFR1) rescued many sympathetic...
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