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Article

Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor.

Journal of neuropathology and experimental neurology - 1 Apr 2003

Petratos Steven, Butzkueven Helmut, Shipham Kylie, Cooper Helen, Bucci Tamara, Reid Kate, Lopes Elizabeth, Emery Ben, Cheema Surindar S, Kilpatrick Trevor J

Abstract excerpt

Schwann cell death is a developmentally regulated phenomenon and is also induced after peripheral nerve axotomy in neonatal rodents. In this study, we explored whether ligand-induced activation of the low-affinity neurotrophin receptor (p75(NTR)) is responsible for inducing Schwann cell death in vivo. Administration of exogenous nerve growth factor (NGF) to the axotomized nerve site in wild-type animals resulted...

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Identifiers

PMID: 12722832
DOI: 10.1093/jnen/62.4.398

Genes

NGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Schwann cell apoptosis in the postnatal axotomized sciatic nerve is mediated via NGF through the low-affinity neurotrophin receptor.PMID 12722832Read ↗

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