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Article

Tumor necrosis factor alpha and human Schwann cells: signalling and phenotype modulation without cell death.

Journal of neuropathology and experimental neurology - 1 Jan 2000

Bonetti B, Valdo P, Stegagno C, Tanel R, Zanusso G L, Ramarli D, Fiorini E, Turazzi S, Carner M, Moretto G

Abstract excerpt

The aim of the study was to evaluate the biological response of human Schwann cells (SC) to tumor necrosis factor alpha (TNFalpha) in vitro and to the inflammatory milieu of chronic inflammatory demyelinating polyradiculoneuritis (CIDP). By immunocytochemical and functional assays, we found that SC expressed TNF receptors and that TNFalpha promoted in SC cultures transient activation of transcription factors...

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Identifiers

PMID: 10744037
DOI: 10.1093/jnen/59.1.74

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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